Characterizing fetal liver and placental steroid and eicosanoid metabolizing enzymes from dams supplemented with melatonin

• Published in: Journal of animal science Vol. 95; p. 60
• Main Authors: McGee, C N, Owen, M P T, McCarty, K J, Hart, C G, Yankey, K C, King, E H, Hopper, R M, Burnett, D D, Lemley, C O
• Format: Journal Article
• Language: English
• Published: Champaign Oxford University Press 01.08.2017
• Subjects: Beef; CYP1A protein; Cytochrome P450; Dams; Enzymatic activity; Enzyme activity; Enzymes; Fetuses; Implants; Liver; Melatonin; Placenta; Steroids; Tissues
• ISSN: 0021-8812; 1525-3163
• DOI: 10.2527/asasann.2017.121

An abstract of a study by McGee et al examining fetal liver and placental steroid and eicosanoid enzyme activity during maternal melatonin supplementation is presented. Activity of CYP1A in CAR was decreased (P = 0.02) in male vs. female fetuses from nonimplant control group (CON) dams. Activity of CYP1A was not different (P ≥ 0.25) in cotyledon (COT) tissues; however, activity of CYP1A in the fetal liver was increased (P = 0.01) in male vs. female fetuses. Activity of CYP2C was observed only in caruncle (CAR) and was not different between treatments (P ≥ 0.59). Activity of CYP3A was observed only in the fetal liver and was not different between treatments (P≥ 0.41). Activity of UGT in COT was decreased (P = 0.03) in male fetuses from melatonin implants (MEL) dams vs female fetuses from MEL dams and male fetuses from CON dams. Activity of UGT was not different (P≥ 0.34) between treatments in CAR; however, activity of UGT was increased (P = 0.002) in the fetal liver from MEL dams compared with the fetal liver from CON dams.