Characterizing fetal liver and placental steroid and eicosanoid metabolizing enzymes from dams supplemented with melatonin
An abstract of a study by McGee et al examining fetal liver and placental steroid and eicosanoid enzyme activity during maternal melatonin supplementation is presented. Activity of CYP1A in CAR was decreased (P = 0.02) in male vs. female fetuses from nonimplant control group (CON) dams. Activity of...
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Published in | Journal of animal science Vol. 95; p. 60 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Champaign
Oxford University Press
01.08.2017
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Subjects | |
Online Access | Get full text |
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Summary: | An abstract of a study by McGee et al examining fetal liver and placental steroid and eicosanoid enzyme activity during maternal melatonin supplementation is presented. Activity of CYP1A in CAR was decreased (P = 0.02) in male vs. female fetuses from nonimplant control group (CON) dams. Activity of CYP1A was not different (P ≥ 0.25) in cotyledon (COT) tissues; however, activity of CYP1A in the fetal liver was increased (P = 0.01) in male vs. female fetuses. Activity of CYP2C was observed only in caruncle (CAR) and was not different between treatments (P ≥ 0.59). Activity of CYP3A was observed only in the fetal liver and was not different between treatments (P≥ 0.41). Activity of UGT in COT was decreased (P = 0.03) in male fetuses from melatonin implants (MEL) dams vs female fetuses from MEL dams and male fetuses from CON dams. Activity of UGT was not different (P≥ 0.34) between treatments in CAR; however, activity of UGT was increased (P = 0.002) in the fetal liver from MEL dams compared with the fetal liver from CON dams. |
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ISSN: | 0021-8812 1525-3163 |
DOI: | 10.2527/asasann.2017.121 |