An efficient and convenient aldol addition of acyldiazomethane with aldehydes promoted by MgI 2 etherate

The aldol addition of acyldiazomethane with aromatic aldehydes, vinyl aldehyde and aliphatic aldehydes was carried out efficiently in the presence of MgI 2 etherate and iPr 2 EtN (DIPEA) using untreated reagent-grade CH 2 Cl 2 under atmospheric conditions in good to excellent yields. Iodide counteri...

Full description

Saved in:
Bibliographic Details
Published inMain group metal chemistry Vol. 40; no. 3-4; p. 87
Main Authors Xie, Xiaoqiang, Qi, Weipeng, Sun, Xinzhe, Zhang, Xingxian
Format Journal Article
LanguageEnglish
Published Berlin Walter de Gruyter GmbH 01.08.2017
Subjects
Aldehydes
Aliphatic compounds
Online AccessGet full text

Cover

More Information
Summary:The aldol addition of acyldiazomethane with aromatic aldehydes, vinyl aldehyde and aliphatic aldehydes was carried out efficiently in the presence of MgI 2 etherate and iPr 2 EtN (DIPEA) using untreated reagent-grade CH 2 Cl 2 under atmospheric conditions in good to excellent yields. Iodide counterion and a non-coordinating reaction media (i.e. CH 2 Cl 2 ) are among the critical factors for the unique reactivity of this reaction system.
ISSN:0792-1241
2191-0219
DOI:10.1515/mgmc-2017-0006