Amalaki Rasayana improved memory and neuronal metabolic activity in A[beta]PP-PS1 mouse model of Alzheimer's disease

Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive loss of memory and cognitive function. The cerebral metabolic rate of glucose oxidation has been shown to be reduced in AD. The present study evaluated efficacy of dietary Amalaki Rasayana (AR),...

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Bibliographic Details
Published inJournal of biosciences Vol. 42; no. 3; p. 363
Main Authors Tiwari, Vivek, Saba, Kamal, Veeraiah, Pandichelvam, Jose, Jedy, Lakhotia, Subhash C, Patel, Anant B
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Nature B.V 01.09.2017
Subjects
Alzheimer's disease
Amino acids
Brain
Cognitive ability
Diet
Donepezil
Glucose
Glutamatergic transmission
Intervention
Labeling
Learning
Magnetic resonance spectroscopy
Memory
Metabolic rate
Metabolism
Mice
Neurodegenerative diseases
Neurons
NMR spectroscopy
Oxidation
Presenilin 1
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Summary:Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive loss of memory and cognitive function. The cerebral metabolic rate of glucose oxidation has been shown to be reduced in AD. The present study evaluated efficacy of dietary Amalaki Rasayana (AR), an Ayurvedic formulation used in Indian traditional system, in A[beta]PP-PS1 mouse model of AD in ameliorating memory and neurometabolism, and compared with donepezil, a standard FDA approved drug for AD. The memory of mice was measured using Morris Water Maze analysis. The cerebral metabolism was followed by 13C labelling of brain amino acids in tissue extracts ex vivo using 1H-[13C]-NMR spectroscopy together with a short time infusion of [1,6-13C2]glucose to mice. The intervention with Amalaki Rasayana showed improved learning and memory in A[beta]PP-PS1 mice. The 13C labelings of GluC4, GABAC2 and GlnC4 were reduced in A[beta]PP-PS1 mice when compared with wild-type controls. Intervention of AR increased the 13C labelling of amino acids suggesting a significant enhancement in glutamatergic and GABAergic metabolic activity in A[beta]PP-PS1 mice similar to that observed with donepezil treatment. These data suggest that AR has potential to improve memory and cognitive function in AD.
ISSN:0250-5991
0973-7138
DOI:10.1007/s12038-017-9692-7