mRNA Expressions of Gamma-Glutamyl Transferase Genes in Different Types of Cancer

According to a database study, while GGT1 mRNA expressions are normally observed in blood and tissues of mammary gland, lymph and prostate and were also detected in tissues of the breast, uterus and lung cancers, and leukemia (Heisterkamp, 2008). According to relative quantification (RQ) values of G...

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Published inFABAD journal of pharmaceutical sciences Vol. 42; no. 1; p. 21
Main Authors Yardim-Akaydin, Sevgi, Deviren, Ceren, Miser-Salihoglu, Ece, Caliskan-Can, Emel, Atalay, M Can
Format Journal Article
LanguageEnglish
Published Ankara Hacettepe University Faculty of Medicine 01.01.2017
Subjects
Amino acids
Breast cancer
Cancer
Enzymes
Gene expression
Genomes
Leukemia
Medical research
Mortality
Nervous system
Pancreas
Prostate
Rodents
Studies
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Summary:According to a database study, while GGT1 mRNA expressions are normally observed in blood and tissues of mammary gland, lymph and prostate and were also detected in tissues of the breast, uterus and lung cancers, and leukemia (Heisterkamp, 2008). According to relative quantification (RQ) values of GGT1, GGT5 and GGT6, tumor mRNA expression greater than twofold relative to the corresponding gene expression in normal tissues was considered to be an overexpression. mRNA expressions in all the patients In this study, mRNA expressions of GGT1 were found higher, but not statistically significant in tumor tissues, than those in the normal tissues for all of the patients (p>0.05) (Table 2, Figure 1a). According to the cancer groups, high RQ values (>1) were observed 85.7% (6/7) for GGT1, 42.9% (3/7) for GGT5, and 14.3% (1/7) for GGT6 in breast cancer group; 66.7% (4/6) for GGT1 and 50% (3/6) for GGT5 in gastric cancer group; 46.2% (6/13) for GGT1, 76.9% (10/13) for GGT5, and 15.4% (2/13) for GGT6 in colon cancer group (Table 2). mRNAs of GGT1, GGT5 and GGT6 were overexpressed in samples from 13 (50 %), 9 (34.6%) and 3 (11.5%) patients, respectively. [...]this is the first study examining GGT1, GGT5 and GGT6 mRNA expressions in normal and tumor tissues of the same patients simultaneously, showing GGT5 for the first time in both normal and tumor tissues of the breast, gastric and the colon.
ISSN:1300-4182