C28 FROM TARGETS TO THERAPIES IN FIBROSIS: A New Xenograft Mouse Model For Idiopathic Pulmonary Fibrosis

The widely used bleomycin model lacks any honeycomb cyst formation and bronchialization. [...]bleomycin induced fibrosis spontaneously resolves. Immunohistochemistry (anti-human nuclei) and GFP tracing revealed massiv engraftment of human IPF ABCs. 3D reconstruction of micr°CT data confirmed the ext...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Prasse, A, Jäger, B, Wirtz, V, Rittinghausen, S, Verleden, S, Sadeleer, L De, Wuyts, W A
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Interferon
Lungs
Pulmonary fibrosis
Rodents
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Summary:The widely used bleomycin model lacks any honeycomb cyst formation and bronchialization. [...]bleomycin induced fibrosis spontaneously resolves. Immunohistochemistry (anti-human nuclei) and GFP tracing revealed massiv engraftment of human IPF ABCs. 3D reconstruction of micr°CT data confirmed the extensive cystic remodelling of lungs. [...]fibrosis did not resolve in mice surviving 8 weeks.
ISSN:1073-449X
1535-4970