A72 MECHANISMS DRIVING FIBROSIS: The Concentration Of Muc5b Is Directly Related To The Severity Of Bleomycin-Induced Lung Injury In Mice

[...]Muc5b-/- mice have less lung collagen following bleomycin treatment than their wild type littermates. Gene expression profiling revealed differences in expression of repair related genes, while tissue staining showed an increase in lung cell apoptosis in MUC5B overexpressing animals.

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Hancock, L A, Hennessy, C E, Dobrinskikh, E, Estrella, A, Yang, I V, Evans, C, Schwartz, D A
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Apoptosis
Collagen
Gene expression
Rodents
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Summary:[...]Muc5b-/- mice have less lung collagen following bleomycin treatment than their wild type littermates. Gene expression profiling revealed differences in expression of repair related genes, while tissue staining showed an increase in lung cell apoptosis in MUC5B overexpressing animals.
ISSN:1073-449X
1535-4970