A73 BEYOND CIGARETTE SMOKE IN COPD: Prostaglandin E2 Attenuates Cigarette Smoke-Induced Cellular Inflammation In A Socs3-Independent Manner

Here, we used a well-characterized murine model of cigarette smoke (CS)-induced inflammation and bacterial exacerbation to investigate the mechanism of induction of PGE2, as well as the contribution of PGE2 to the inflammatory cellular profile associated with COPD. Methods: 6-8 week old BALB/c, C57B...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Stampfli, M R, Thayaparan, D, Roos, A, Divangahi, M, Beaulieu, A J
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Bacterial infections
Chronic obstructive pulmonary disease
Infections
Inflammation
Lungs
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Summary:Here, we used a well-characterized murine model of cigarette smoke (CS)-induced inflammation and bacterial exacerbation to investigate the mechanism of induction of PGE2, as well as the contribution of PGE2 to the inflammatory cellular profile associated with COPD. Methods: 6-8 week old BALB/c, C57BL/6, and microsomal prostaglandin E synthase (mPGES)-1-deficient (Ptges-/-) mice were exposed to CS for 4 days and 8 weeks, using a whole-body smoke exposure system.
ISSN:1073-449X
1535-4970