A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: Camkii Is Necessary For Increased Proliferation And Migration Of Pulmonary Arterial Smooth Muscle Cells In Pulmonary Hypertension

Methods: PASMCs were isolated from male Wistar rats exposed to the vascular endothelial growth factor receptor inhibitor SU5416 plus 3 wk of 10% oxygen followed by 2 wk of normoxia (SuHx model), and control rats exposed to vehicle and 5 wk of normoxia. Results: SuHx rats developed severe PH as measu...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Huetsch, J, Jiang, H, Shimoda, L
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Kinases
Pulmonary hypertension
Rodents
Smooth muscle
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Summary:Methods: PASMCs were isolated from male Wistar rats exposed to the vascular endothelial growth factor receptor inhibitor SU5416 plus 3 wk of 10% oxygen followed by 2 wk of normoxia (SuHx model), and control rats exposed to vehicle and 5 wk of normoxia. Results: SuHx rats developed severe PH as measured by increase in right ventricular systolic pressure and right ventricular hypertrophy, as well as presence of pulmonary vascular remodeling including medial thickening and vaso-occlusive lesions.
ISSN:1073-449X
1535-4970