C27 LET'S PRETEND WE'RE MARRIED: THE RIGHT VENTRICLE AND THE PULMONARY VASCULATURE: Endothelial Cell Hypoxia-Inducible Factor (hif) Activity Is Necessary For Right Ventricular Remodeling In A Murine Model Of Chronic-Hypoxic Pulmonary Hypertension

Endothelial cell (EC) expression of HIF-1 is necessary for adaptive LV remodeling during chronic pressure overload, with loss of EC-specific HIF-1 activity associated with reduced LV capillary density. Conditional transgenic mice lacking expression of the obligate HIF-1a/HIF-2a co-factor ARNT (aryl...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Kolb, T M, Singer, B D, D'Alessio, F R, Damarla, M, Damico, R L, Hassoun, P M, Semenza, G, Shimoda, L
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Angiogenesis
Hypoxia
Pulmonary hypertension
Rodents
Online AccessGet full text

Cover

More Information
Summary:Endothelial cell (EC) expression of HIF-1 is necessary for adaptive LV remodeling during chronic pressure overload, with loss of EC-specific HIF-1 activity associated with reduced LV capillary density. Conditional transgenic mice lacking expression of the obligate HIF-1a/HIF-2a co-factor ARNT (aryl hydrocarbon receptor nuclear translocator) in Tie2+ lineage cells (ARNTf1/f1;Tie2-Cre+) and ARNT-expressing control mice (ARNTf1/f1;Tie2-Cre-) were exposed to normobaric hypoxia (10% FiO2) for 1-5 weeks.
ISSN:1073-449X
1535-4970