D30 NEW INSIGHTS INTO OBSTRUCTIVE SLEEP APNEA PATHOGENESIS: Classical Heritability Of Upper Airway Anatomy In Twins

Given this existing evidence that underlying genetic factors may determine the development of UA soft tissue and craniofacial structures, we hypothesized that their 3-dimensional sizes obtained via MRI would be more similar in monozygotic twins than dizygotic twins. With Amira software version 5.2.2...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Mellia, J, Keenan, B, Leinwand, S E, Wiemken, A, Hoge, C, Schwab, R J
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Gender
Sleep apnea
Twins
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Summary:Given this existing evidence that underlying genetic factors may determine the development of UA soft tissue and craniofacial structures, we hypothesized that their 3-dimensional sizes obtained via MRI would be more similar in monozygotic twins than dizygotic twins. With Amira software version 5.2.2, 3-dimensional volumes of UA soft tissues and measurements of craniofacial angles, distances, length/height and areas were measured. 2 We used the classical approach to assess broad sense heritability (h ; the proportion of phenotypic variability due to genetic factors) of UA 2 anatomic phenotypes.
ISSN:1073-449X
1535-4970