C15 WHEN MICROBES ATTACK: HOST-PATHOGEN INTERACTIONS: Riboflavin Metabolism Variation Among Clinical Isolates Of Streptococcus Pneumoniae Results In Differential Activation Of Mait Cells

Methods: In this study, we tested a panel of clinical isolates of S. pneumoniae serotype 19A, which has emerged as one of the most prevalent causes of invasive pneumococcal disease, to determine their ability to activate MAIT cells using an IFN-γ ELISPOT assay. [...]we showed that while all S. pneum...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Harriff, M, McMurtrey, C, Hartmann, N, Sorensen, M, Mizgerd, J P, Hildebrand, W, Kronenberg, M, Lewinsohn, D M
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Biosynthesis
Enzymes
Metabolism
Streptococcus infections
Vaccines
Vitamin B
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Summary:Methods: In this study, we tested a panel of clinical isolates of S. pneumoniae serotype 19A, which has emerged as one of the most prevalent causes of invasive pneumococcal disease, to determine their ability to activate MAIT cells using an IFN-γ ELISPOT assay. [...]we showed that while all S. pneumoniae isolates infect airway epithelial cells through adherence, only the growth of bacterial isolates that expressed MR1 ligands was controlled by MAIT cells.
ISSN:1073-449X
1535-4970