A13 ROLE OF DYSBIOSIS IN LUNG DISEASE: Lung Microbiota Are Altered In A Murine Model Of Pulmonary Fibrosis And Are Necessary For Pathogenesis

Rationale: The pathophysiology of Idiopathic Pulmonary Fibrosis (IPF), a fatal interstitial lung disease, is poorly understood. When germ-free mice were challenged with bleomycin instillation, they did not develop pulmonary fibrosis as assessed by hydroxyproline concentration.

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors O'Dwyer, D N, Ashley, S L, Wilke, C A, Falkowski, N R, Huffnagle, G, Moore, B B, Dickson, R P
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Lung diseases
Lungs
Pathogenesis
Pulmonary fibrosis
Rodents
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Summary:Rationale: The pathophysiology of Idiopathic Pulmonary Fibrosis (IPF), a fatal interstitial lung disease, is poorly understood. When germ-free mice were challenged with bleomycin instillation, they did not develop pulmonary fibrosis as assessed by hydroxyproline concentration.
ISSN:1073-449X
1535-4970