A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: Endostatin Suppresses The Inhibitors Of Dna Binding/differentiation Transcription Factors (id1) And Promotes Pulmonary Artery Endothelial Cell Death

• Published in: American journal of respiratory and critical care medicine Vol. 195
• Main Authors: Goyanes, A, Wang, L, Varela, L, Johnston, L, Aladdin, M, Kolb, T M, Hassoun, P M, Damico, R L
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 01.01.2017
• Subjects: Apoptosis; Cell death; Hypertension; Protein expression; Proteins; Pulmonary arteries

ID1 is a transcriptional regulator implicated in cell growth, differentiation, apoptosis, and angiogenesis and an established target of the TGF beta superfamily signaling pathway. Conclusions: ES exposure results in the rapid loss of ID1 protein expression in human PAEC via a proteasome-dependent, p...