A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: Endostatin Suppresses The Inhibitors Of Dna Binding/differentiation Transcription Factors (id1) And Promotes Pulmonary Artery Endothelial Cell Death

ID1 is a transcriptional regulator implicated in cell growth, differentiation, apoptosis, and angiogenesis and an established target of the TGF beta superfamily signaling pathway. Conclusions: ES exposure results in the rapid loss of ID1 protein expression in human PAEC via a proteasome-dependent, p...

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Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Goyanes, A, Wang, L, Varela, L, Johnston, L, Aladdin, M, Kolb, T M, Hassoun, P M, Damico, R L
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Apoptosis
Cell death
Hypertension
Protein expression
Proteins
Pulmonary arteries
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Summary:ID1 is a transcriptional regulator implicated in cell growth, differentiation, apoptosis, and angiogenesis and an established target of the TGF beta superfamily signaling pathway. Conclusions: ES exposure results in the rapid loss of ID1 protein expression in human PAEC via a proteasome-dependent, post-transcriptional mechanism, and promotes PAEC apoptosis.
ISSN:1073-449X
1535-4970