C107 MITOCHONDRIA AND METABOLIC ALTERATIONS IN LUNG DISEASE: De Novo Serine/glycine Synthesis Is Required For Tgf-β-Induced Collagen Production In Human Lung Fibroblasts

Inhibition of glycolysis or the de novo serine/glycine synthesis pathway attenuated collagen protein accumulation without effecting SMAD phosphorylation or TGF-ß induced gene expression. Conclusions: TGF-ß upregulates glycolysis to promote de novo serine biosynthesis, which is required for de novo g...

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Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Nigdelioglu, R, Hamanaka, R B, Meliton, A Y, O'Leary, E, Witt, L J, Sun, K, Woods, P S, Wu, D, Dulin, N O, Chandel, N S, Mutlu, G M
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Biosynthesis
Collagen
Enzymes
Fibroblasts
Gene expression
Metabolism
Proteins
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Summary:Inhibition of glycolysis or the de novo serine/glycine synthesis pathway attenuated collagen protein accumulation without effecting SMAD phosphorylation or TGF-ß induced gene expression. Conclusions: TGF-ß upregulates glycolysis to promote de novo serine biosynthesis, which is required for de novo glycine synthesis in lung fibroblasts.
ISSN:1073-449X
1535-4970