C29 ADVANCES IN PULMONARY IMAGING TO STUDY LUNG STRUCTURE AND FUNCTION: Muc5b Promoter Polymorphism Rs35705950 Is Associated With CT Evidence Of Interstitial Lung Abnormalities Using Visual Reads From The Spiromics Cohort

SPIROMICS Corresponding author's email: woneal@med.unc.edu Introduction: The minor allele of single nucleotide polymorphism (SNP) rs35705950 in the mucin 5B (MUC5B) gene is a strong genetic risk factor for development of idiopathic pulmonary fibrosis (IPF). Rs35705950 was independently predicti...

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Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors O'Neal, W, Hoffman, E A, Dang, H, Barr, R G, Basta, P, Bleecker, E, Boucher, R C, Bowler, R, Christenson, S A, Carretta, E E, Doerschuk, C M, Drummond, M B, Han, M K, Hansel, N N, Hawkins, G, Kaner, R J, Martinez, F J, Meyers, D, Woodruff, P G, Ortega, V E, Couper, D, Newell, J D
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Bronchitis
Emphysema
Pulmonary fibrosis
Regression analysis
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Summary:SPIROMICS Corresponding author's email: woneal@med.unc.edu Introduction: The minor allele of single nucleotide polymorphism (SNP) rs35705950 in the mucin 5B (MUC5B) gene is a strong genetic risk factor for development of idiopathic pulmonary fibrosis (IPF). Rs35705950 was independently predictive (p=0.0026) of visual CT evidence of ILA in NHW at risk-smokers and COPD subjects in a multivariate model that also included covariates for lung function, current smoking status, age, gender, smoking pack years, presence of emphysema, and indications of chronic bronchitis.
ISSN:1073-449X
1535-4970