C15 WHEN MICROBES ATTACK: HOST-PATHOGEN INTERACTIONS: Interleukin-13 Predisposes To More Severe Influenza Infection In Mice And Human Epithelial Cells By Suppressing Interferon Responses And Activating The Microrna-21/pi3k Signaling Pathway

• Published in: American journal of respiratory and critical care medicine Vol. 195
• Main Authors: Starkey, M R, Dua, K, Hsu, A C, Nair, P M, Haw, T J, Nguyen, D H, Kim, R Y, Horvat, J C, Godfrey, D I, McKenzie, A, Lukacs, N W, Wark, P A B, Hansbro, P M
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 01.01.2017
• Subjects: Asthma; Chronic obstructive pulmonary disease; Cytokines; Disease; Infections; Influenza; Rodents

Mice were subjected to Ovalbumin (Ova)-, house dust mite (HDM)- or recombinant interleukin-13 (IL-13)-induced models of allergic airway disease (AAD), or cigarette smoke-induced experimental COPD and infected with influenza virus (A/PR/8/34). Complementary in vitro studies using bronchial epithelial...