C15 WHEN MICROBES ATTACK: HOST-PATHOGEN INTERACTIONS: Interleukin-13 Predisposes To More Severe Influenza Infection In Mice And Human Epithelial Cells By Suppressing Interferon Responses And Activating The Microrna-21/pi3k Signaling Pathway

Mice were subjected to Ovalbumin (Ova)-, house dust mite (HDM)- or recombinant interleukin-13 (IL-13)-induced models of allergic airway disease (AAD), or cigarette smoke-induced experimental COPD and infected with influenza virus (A/PR/8/34). Complementary in vitro studies using bronchial epithelial...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Starkey, M R, Dua, K, Hsu, A C, Nair, P M, Haw, T J, Nguyen, D H, Kim, R Y, Horvat, J C, Godfrey, D I, McKenzie, A, Lukacs, N W, Wark, P A B, Hansbro, P M
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Asthma
Chronic obstructive pulmonary disease
Cytokines
Disease
Infections
Influenza
Rodents
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Summary:Mice were subjected to Ovalbumin (Ova)-, house dust mite (HDM)- or recombinant interleukin-13 (IL-13)-induced models of allergic airway disease (AAD), or cigarette smoke-induced experimental COPD and infected with influenza virus (A/PR/8/34). Complementary in vitro studies using bronchial epithelial cells (pBECs) from healthy individuals, asthmatics and COPD patients were performed.
ISSN:1073-449X
1535-4970