C34 MECHANISMS OF HOST DEFENSE IN BACTERIAL AND FUNGAL INFECTIONS: Il-11 Is Required For Neutrophil Recruitment And Lung Protection During Pneumonia

While other IL-6 family members expressed in pneumonic lungs appear to promote either inflammation (IL-6 and oncostatin M) or tissue protection (leukemia inhibitory factor), IL-11 curiously mediated both in our current study. Surprisingly, IL-11-driven neutrophil recruitment was not associated with...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Traber, K E, Symer, E M, Kim, Y, Jones, M R, Mizgerd, J P, Quinton, L J
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Chemokines
Cytokines
Edema
Inflammation
Lungs
Neutrophils
Pneumonia
Rodents
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Summary:While other IL-6 family members expressed in pneumonic lungs appear to promote either inflammation (IL-6 and oncostatin M) or tissue protection (leukemia inhibitory factor), IL-11 curiously mediated both in our current study. Surprisingly, IL-11-driven neutrophil recruitment was not associated with reductions in ELR-positive CXC chemokines, suggesting alternative pathways of neutrophilic inflammation downstream of this cytokine. [...]the increase in lung injury following IL-11 neutralization was associated with decreased neutrophil numbers, suggesting that injury was not a consequence of excessive neutrophils.
ISSN:1073-449X
1535-4970