C31 BASIC AND TRANSLATIONAL STUDIES ON THE ROLE OF THE EPITHELIUM: Dynamic Regulation Of Circadian Clock Genes In Chronic Airway Disease

Compared to normal controls, airway epithelial cells from both asthma and COPD patients showed significantly increased amplitudes in clock gene expression, but similar period durations, mean expression, and phase. Conclusions: Both asthma and COPD are associated with increased circadian effects at t...

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Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Kenfield, M, Yu, H, Ehlers, A, Xie, W, Gunsten, S, Agapov, E, Horani, A, Holtzman, M J, Brody, S L, Haspel, J
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Asthma
Biological clocks
Circadian rhythm
Gene expression
Viral infections
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Summary:Compared to normal controls, airway epithelial cells from both asthma and COPD patients showed significantly increased amplitudes in clock gene expression, but similar period durations, mean expression, and phase. Conclusions: Both asthma and COPD are associated with increased circadian effects at the level of clock gene expression within airway epithelial cells.
ISSN:1073-449X
1535-4970