D110 CELLULAR AND MOLECULAR INVESTIGATIONS IN THORACIC ONCOLOGY: Tumor Vaccination Combined With Checkpoint Blockade Cooperatively Inhibits Tumor Growth In A Krasg12d Murine Model Of Non-Small Cell Lung Cancer (nsclc)
Adaptive immune resistance is a mechanism by which tumor cells limit host immune response via upregulation of programmed death-ligand 1 (PD-L1) and its ligation to the programmed death-1 (PD-1) receptor on antigen-specific CD8+ T cells. Immunohistochemistry (IHC) and flow cytometry (FACS) were utili...
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Published in | American journal of respiratory and critical care medicine Vol. 195 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
American Thoracic Society
01.01.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Adaptive immune resistance is a mechanism by which tumor cells limit host immune response via upregulation of programmed death-ligand 1 (PD-L1) and its ligation to the programmed death-1 (PD-1) receptor on antigen-specific CD8+ T cells. Immunohistochemistry (IHC) and flow cytometry (FACS) were utilized to evaluate immune cell number and effector function along with expression of immune checkpoint proteins. |
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ISSN: | 1073-449X 1535-4970 |