D110 CELLULAR AND MOLECULAR INVESTIGATIONS IN THORACIC ONCOLOGY: Tumor Vaccination Combined With Checkpoint Blockade Cooperatively Inhibits Tumor Growth In A Krasg12d Murine Model Of Non-Small Cell Lung Cancer (nsclc)

Adaptive immune resistance is a mechanism by which tumor cells limit host immune response via upregulation of programmed death-ligand 1 (PD-L1) and its ligation to the programmed death-1 (PD-1) receptor on antigen-specific CD8+ T cells. Immunohistochemistry (IHC) and flow cytometry (FACS) were utili...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Salehi-Rad, R, Walser, T, Ong, S, Park, S J, Sharma, S, Dubinett, S
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Antigens
Lung cancer
Lymphocytes
Rodents
T cell receptors
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Summary:Adaptive immune resistance is a mechanism by which tumor cells limit host immune response via upregulation of programmed death-ligand 1 (PD-L1) and its ligation to the programmed death-1 (PD-1) receptor on antigen-specific CD8+ T cells. Immunohistochemistry (IHC) and flow cytometry (FACS) were utilized to evaluate immune cell number and effector function along with expression of immune checkpoint proteins.
ISSN:1073-449X
1535-4970