C73 NEW MECHANISMS AND THERAPIES IN COPD: Function Of Lypd2 (ly6/pla Ur Domain Category 2) In Maintaining Normal Airway Differentiation

Rationale: LYPD2 (LY6/PLAUR domain category 2), a paralog of SLURP1, is a gene of unknown function expressed at high levels in the normal human airway epithelium. Based on observations that SLURP1 is a positive modulator of the a7 nicotinic receptor expressed on airway epithelium where it acts to de...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Salit, J, Walters, M S, Zhang, H, Tang, Y, Crystal, R G
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Chronic obstructive pulmonary disease
Mucous membrane
Online AccessGet full text

Cover

More Information
Summary:Rationale: LYPD2 (LY6/PLAUR domain category 2), a paralog of SLURP1, is a gene of unknown function expressed at high levels in the normal human airway epithelium. Based on observations that SLURP1 is a positive modulator of the a7 nicotinic receptor expressed on airway epithelium where it acts to defend the respiratory epithelium by suppressing responses to inflammatory stimuli, we hypothesized that LYPD2 may function in a parallel fashion.
ISSN:1073-449X
1535-4970