C51 CRITICAL CARE: MORE NON-PULMONARY CRITICAL CARE PROBLEMS: Hemophagocytic Lymphohistiocytosis In Critical Illness: A Retrospective Chart Review

Introduction Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by activation of T lymphocytes and macrophages, resulting in a cytokine storm and multi-system organ failure, often requiring management in the intensive care setting. Because the treatment of HLH may include targ...

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Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Hermann, E, Li, J, Abrams, D C, Agerstrand, C, Eisenberger, A, O'Donnell, M R
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Critical care
Illnesses
Lymphatic diseases
New York
United States > US
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Summary:Introduction Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by activation of T lymphocytes and macrophages, resulting in a cytokine storm and multi-system organ failure, often requiring management in the intensive care setting. Because the treatment of HLH may include targeted therapies, identifying critically ill patients with HLH is essential. Methods Using a targeted search strategy we identified adult patients admitted between 2008 and 2016 whose electronic medical record (EMR) contained an ICD-9 or ICD-10 code for HLH, elevated soluble IL2 receptor and/or who had hemophagocytosis on biopsy.
ISSN:1073-449X
1535-4970