C80-C IMAGING METHODOLOGY AND APPLICATION TO LUNG DISEASE: Analysis Of Radioaerosol Distribution From Pulmonary 2d Scintigraphy Using Anatomical 3d Information

Introduction:The planar scintigraphy of pulmonary inhalation is a two-dimensional (2D) technology widely used to evaluate the aerosol deposition but it is insensitive to regional differences in aerosol concentration, particularly those related to the lung depth, and may miss-estimate deposition dist...

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Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Alcoforado, L, De Andrade, A Dornelas, Herraiz, J Lopez, Brandao, S S, Barcelar, J De Melo, Fink, J, Venegas, J G
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
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Summary:Introduction:The planar scintigraphy of pulmonary inhalation is a two-dimensional (2D) technology widely used to evaluate the aerosol deposition but it is insensitive to regional differences in aerosol concentration, particularly those related to the lung depth, and may miss-estimate deposition distribution between central and peripheral airways. Aims:1) present a novel method to analyze scintigraphic images of radio-aerosol deposition, based on anatomically consistent regions of interest (ROIs), that allows estimation of aerosol distribution between central and peripheral airways and 2) compare the repeatability of these estimates against those derived from manually traced ROIs.Methods:Scintigraphic images of 16 subjects with a clinical diagnosis of moderate-to-severe asthma were evaluated using a custom software that scaled 3D anatomical features, obtained from population averaged high resolution computed tomography (HRCT) chest scans onto scintigraphic 2D images.
ISSN:1073-449X
1535-4970