A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: Microvascular Endothelial Cells Of Pulmonary Arterial Hypertension Patients Are More Sensitive To Bmp9 Stimulation And Activate Both The Bmp And Tgf-Beta Signaling Cascade

RATIONALE Pulmonary Arterial Hypertension (PAH) is characterized by a disbalance in transforming growth factor beta (TGFb) and bone morphogenetic protein (BMP) signaling. The anti-proliferative BMP signaling is decreased in the PAH lung, while elevated levels of circulating TGFb enhances the prolife...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Rol, N, Szulcek, R, Kurakula, K, Pan, X, Dickhoff, C, Vonk-Noordegraaf, A, Goumans, M T H, Bogaard, H J
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Circulatory system
Hypertension
Kinases
Nitric oxide
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Summary:RATIONALE Pulmonary Arterial Hypertension (PAH) is characterized by a disbalance in transforming growth factor beta (TGFb) and bone morphogenetic protein (BMP) signaling. The anti-proliferative BMP signaling is decreased in the PAH lung, while elevated levels of circulating TGFb enhances the proliferation of vascular cells leading to occlusive remodeling in the pulmonary vasculature.
ISSN:1073-449X
1535-4970