ANTIOXIDANT AND ANTICANCER ACTIVITIES OF Phyllanthus reteculatus

Medicinal plants contain physiologically active principles that over the years have been exploited in traditional medicine for the treatment of various ailments. The methanolic extract of Phyllanthus reteculatus was tested in-vitro as antioxidant and anticancer agent as well as for its phenolic and...

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Published inPharmacie Globale : International Journal of Comprehensive Pharmacy Vol. 7; no. 2; p. 1
Main Authors Ibrahim, Elwaleed E, Abdalla, Ashraf N
Format Journal Article
LanguageEnglish
Published Roorkee Pharmacie Globale 01.04.2016
Subjects
Anticancer properties
Antioxidants
Antitumor activity
Ascites
Cancer
Colorimetry
Cytotoxicity
Deoxyribonucleic acid
Dietary supplements
Disease
DNA
Enzymes
Ethanol
Flavonoids
Free radicals
Hepatitis
Herbal medicine
Medicinal plants
Medicine
Natural products
Pharmacology
Phenolic compounds
Phenols
Plant extracts
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Summary:Medicinal plants contain physiologically active principles that over the years have been exploited in traditional medicine for the treatment of various ailments. The methanolic extract of Phyllanthus reteculatus was tested in-vitro as antioxidant and anticancer agent as well as for its phenolic and flavonoidal contents. The antioxidant activity of the plant extract was determined by 2, 2 diphenyl -1 -picrylhydrazyl (DPPH) assay while the trypan blue technique was used for the anticancer activity against Ehrlich Ascites Carcinoma Cells (EACC). The total phenolic and flavonoidal contents were estimated using colorimetric methods. The methanolic extract at a concentration of 13μg/ml possessed a considerable antioxidant activity against DPPH radical. Moreover, it caused 100% cytotoxic effect against EACC. Phyllanthus reteculatus extract was found to contain appreciable amounts of phenolic and flavonoidal compounds. It can be concluded that Phyllanthus reteculatus possesses sufficient in-vitro antioxidant and anticancer activities to warrant further detailed study of its pharmacology and phytochemistry.
ISSN:0976-8157
0976-8157