Update on Continuous Bioprocessing: From the Industry’s Perception to Reality

While biopharmaceuticals may be one of the most complex and profitable high-technology products, the fundamental aspects of manufacturing have not changed in decades. This contrasts with other manufacturing industries, such as steel or chemical, which have adopted continuous manufacturing. Continuou...

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Bibliographic Details
Published inPharmaceutical technology Europe Vol. 29; no. 6; p. 6
Main Authors Langer, Eric, Estes, Kathleen A
Format Journal Article
LanguageEnglish
Published Monmouth Junction MultiMedia Healthcare Inc 01.06.2017
Subjects
Annual reports
Batch processing
Capital costs
Chromatography
Continuous processing
Cost control
FDA approval
Flexibility
Manufacturers
Manufacturing
Perceptions
Process controls
Product quality
Production capacity
Regulatory agencies
Technology
United States > US
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Summary:While biopharmaceuticals may be one of the most complex and profitable high-technology products, the fundamental aspects of manufacturing have not changed in decades. This contrasts with other manufacturing industries, such as steel or chemical, which have adopted continuous manufacturing. Continuous manufacturing can be more efficient and cost effective than current methods of manufacturing. But until recently, the technologies to accomplish commercial-scale continuous manufacturing have been works in progress. In continuous processing, the processed products are moved to the next step as each unit process is completed. This process can provide considerable benefit to the manufacturers by being more cost-effective, requiring less infrastructure, less space, less investment, less staff, all while manufacturing products in the same or perhaps less time than traditional batch methods. Although widespread adoption of continuous bioprocessing has been slow, some processes in the industry, such as perfusion, have been an exception. For the most part, continuous bioprocessing is dominated by smaller-scale perfusion, increasingly single-use, bioreactors.
ISSN:1753-7967