Comparison of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for diagnosis of latent tuberculosis in haemodialysis (HD) patients: a meta-analysis of [...]estimates

• Published in: Epidemiology and infection Vol. 145; no. 9; p. 1824
• Main Authors: AYUBI, E, DOOSTI-IRANI, A, SANJARI MOGHADDAM, A, KHAZAEI, S, MANSORI, K, SAFIRI, S, SANI, M, MOSTAFAVI, E
• Format: Journal Article
• Language: English
• Published: Cambridge Cambridge University Press 01.07.2017
• Subjects: Age; Agreements; Bacillus Calmette-Guerin vaccine; BCG; Clinical medicine; Confidence intervals; Cut-off; Diagnosis; Discordance; Epidemiology; Estimates; Hemodialysis; Infections; Literature reviews; Medical diagnosis; Meta-analysis; Methods; Nephrology; Patients; Public health; Quality; Regression analysis; Searching; Skin tests; Studies; Transplants & implants; Tuberculin; Tuberculosis; Vaccination
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268817000334

SUMMARY Diagnosis of latent tuberculosis infection (LTBI) is a concern in haemodialysis (HD) patients. Many studies have compared QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for detecting LTBI and reported the [...]statistic of agreement between QFT-GIT and TST in HD patients. The present study aimed to systematically review this literature and conduct meta-analysis of individual studies that estimated the [...]between QFT-GIT with TST among HD patients. All relevant published studies that were available as full-text were obtained by searching Medline (1950), Web of Sciences (1945), Scopus (1973) through May 2016. The [...]was re-estimated from the individual studies and pooled using random effect meta-analysis. Subgroup analysis and meta-regression were applied to evaluate the effect of Bacillus Calmette-Guérin (BCG) vaccination, TST cut-off points, quality of studies, sample size and age on variation of [...]estimate. Eight studies involving 901 HD patients were included in meta-analysis. The pooled [...]estimate was 0·28 (I 2 = 18·4%, P = 0·239, 95% confidence intervals 0·22-0·34). The discordance of TST-/QFT-GIT+ was more than TST+/QFT-GIT-. History of BCG vaccination, TST cut-off points and age are related to variation of [...]estimates. TST and QFT-GIT are not comparable in detecting LTBI in HD patients. The higher TST-/QFT-GIT+ ratio compared with TST+/QFT-GIT- ratio, may indicate the superiority of QFT-GIT over TST for detection LTBI in HD patients.