(C6F5)3B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with [alpha]-Aryl [alpha]-Diazoesters

The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with [alpha]-aryl [alpha]-diazoacetates with comm...

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Bibliographic Details
Published inAngewandte Chemie Vol. 128; no. 47; p. 15027
Main Authors Yu, Zhunzhun, Li, Yongfeng, Shi, Jiameng, Ma, Ben, Liu, Lu, Zhang, Junliang
Format Journal Article
LanguageGerman
Published Weinheim Wiley Subscription Services, Inc 14.11.2016
Subjects
Aromatic compounds
Catalysts
Chemistry
Phenols
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Summary:The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with [alpha]-aryl [alpha]-diazoacetates with commercially available (C6F5)3B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201608937