Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/[beta]-catenin pathway

As the eighth most common malignant tumour worldwide, oesophageal cancer (OC) is often diagnosed during the metastasis of its advanced stage. Interleukin (IL)-23 is an immunomodulatory cytokine that has recently been identified as a cancer-associated factor. However, the role of IL-23 in the evoluti...

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Published inScientific reports Vol. 5; p. 8604
Main Authors Chen, Deyu, Li, Wei, Liu, Shenzha, Su, Yuting, Han, Guohu, Xu, Chenchen, Liu, Hongli, Zheng, Tingting, Zhou, Yuepeng, Mao, Chaoming
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 01.02.2015
Subjects
Cytokines
Esophageal cancer
Esophagus
Immunomodulation
Interleukin 23
Mesenchyme
Metastases
Metastasis
Tumors
Wnt protein
β-Catenin
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Summary:As the eighth most common malignant tumour worldwide, oesophageal cancer (OC) is often diagnosed during the metastasis of its advanced stage. Interleukin (IL)-23 is an immunomodulatory cytokine that has recently been identified as a cancer-associated factor. However, the role of IL-23 in the evolution of OC remains unclear. In the present study, we found that IL-23 was significantly expressed in the tumours of OC patients suffering metastasis and demonstrated that IL-23 contributed to epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin pathway, promoting the migration and invasion of OC cells. In conclusion, IL-23 plays a pivotal role in the development of OC via EMT.
ISSN:2045-2322
DOI:10.1038/srep08604