Caspase 3, 6, 8, and 9 Gene Expression in Peripheral Blood Leukocytes and Plasma Concentrations of IL-6 and TNF-[alpha] in Carriers of Different Polymorphic Marker -174G>C Genotypes of IL6 Gene Associated with the Risk of Nonalcoholic Steatohepatitis

We revealed an association of IL6 gene -174G>C polymorphism with the development of nonalcoholic steatohepatitis in the Russian population. The risk is significantly higher in carriers of C allele: OR=1.77 (1.04; 3.02). The effects of -174G>C substitution in IL6 gene involving caspase 9 gene t...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 162; no. 3; p. 370
Main Authors Kurbatova, I V, Topchieva, L V, Dudanova, O P
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.01.2017
Subjects
Alleles
Caspase
Caspase-3
Caspase-9
Gene expression
Gene polymorphism
Interleukin 6
Leukocytes
Peripheral blood
Population genetics
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Summary:We revealed an association of IL6 gene -174G>C polymorphism with the development of nonalcoholic steatohepatitis in the Russian population. The risk is significantly higher in carriers of C allele: OR=1.77 (1.04; 3.02). The effects of -174G>C substitution in IL6 gene involving caspase 9 gene transcripts in peripheral blood leukocytes and on blood content of TNF-[alpha] in healthy individuals without clinical manifestations of nonalcoholic steatohepatitis were detected. The content of caspase 9 gene transcripts in peripheral blood leukocytes and plasma level of TNF-[alpha] were significantly higher in healthy subjects carrying C allele than in carriers of GG genotype. The levels of caspases 3, 6, 8, and 9 gene transcripts in peripheral blood leukocytes and plasma concentrations of TNF-[alpha] in patients with nonalcoholic steatohepatitis did not depend on IL6 genotype by -174G<C marker.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3618-0