Insertion of Isolated Alkynes into Carbon-Carbon [sigma]-Bonds of Unstrained Cyclic [beta]-Ketoesters via Transition-Metal-Free Tandem Reactions: Synthesis of Medium-Sized Ring Compounds

The transition-metal-free insertion of isolated alkynes into carbon-carbon σ-bonds of unstrained cyclic [beta]-dicarbonyl compounds has been reported. These tandem reactions offer an efficient synthesis of medium-sized ring or fused-ring compounds through ring expansion. The methodology has the pote...

Full description

Saved in:
Bibliographic Details
Published inChemistry : a European journal Vol. 22; no. 50; p. 17936
Main Authors Zhou, Yuanyuan, Tao, Xianghua, Yao, Qiyi, Zhao, Yulei, Li, Yanzhong
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 12.12.2016
Subjects
Carbon
Chemical bonds
Chemistry
Online AccessGet full text

Cover

More Information
Summary:The transition-metal-free insertion of isolated alkynes into carbon-carbon σ-bonds of unstrained cyclic [beta]-dicarbonyl compounds has been reported. These tandem reactions offer an efficient synthesis of medium-sized ring or fused-ring compounds through ring expansion. The methodology has the potential to be widely used throughout organic synthesis due to the easily accessible starting materials and mild reaction conditions.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201603798