CONFIDENCE REGION DETERMINATION AND BIOPHYSICAL INTERPRETATION OF WATER-MOLECULE DIFFUSION PARAMETERS DETERMINED BY MAGNETIC RESONANCE DIFFUSION TENSOR AND DIFFUSION KURTOSIS IMAGING IN THE MOUSE BRAIN

The transition between free and restricted diffusion was examined with a simple 1D-3D Monte-Carlo water molecule mobility model, which confirmed the distribution function evolution and demonstrated the transformation of the exponential signal model exp(-b.D) used in DTI through exp(-bD+b2D2K/6) used...

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Bibliographic Details
Published inPhysiological research Vol. 65; no. 4; p. 4P
Main Authors Starcuk, Z, Drazanova, E, Dvorakova, L
Format Journal Article
LanguageEnglish
Published Praha Institute of Physiology 01.07.2016
Subjects
Confidence
Diffusion
Normal distribution
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Summary:The transition between free and restricted diffusion was examined with a simple 1D-3D Monte-Carlo water molecule mobility model, which confirmed the distribution function evolution and demonstrated the transformation of the exponential signal model exp(-b.D) used in DTI through exp(-bD+b2D2K/6) used for DKI to a leveling-off model definitely necessary for b>3/D/K when the kurtosis model fails to properly model further signal loss with growing b. Larger number of parameters or model inappropriateness are connected with larger confidence regions.
ISSN:0862-8408
1802-9973