The Synthesis of 7-Substituted-3-dinitrostyryl Cephalosporins and Their Ability for Detecting Extended Spectrum [beta]-Lactamases (ESBLs)

• Published in: Journal of antibiotics Vol. 58; no. 1; p. 69
• Main Authors: Hanaki, Hideaki, Yamazaki, Hiroaki, Harada, Hidenori, Kubo, Ryoichi, Kobayashi, Takayoshi, Atsuda, Koichiro, Sunakawa, Keisuke
• Format: Journal Article
• Language: English
• Published: Tokyo Nature Publishing Group 01.01.2005
• Subjects: Acetic acid

AbstractWe synthesized 7-substituted-3-(2,4-dinitrostyryl)cephalosporin derivatives which were Nitrocefin analogs, for detecting extended spectrum β-lactamase (ESBL) specifically. HMRZ-86 which has carboxypropyloxyimino group on 7-aminothiazolacetamide substituent were not hydrolyzed by class A, C a...