No association between asthma or allergy and the CCR5[Delta] 32 mutation

Aims: To investigate whether the presence of the CCR5Δ32 allele was associated with atopy or asthma. Methods: A total of 118 children with asthma, 145 children with non-asthmatic, but allergic phenotype, and 303 children without allergic or asthmatic disorders were studied. Results: There were no si...

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Bibliographic Details
Published inArchives of disease in childhood Vol. 86; no. 6; p. 426
Main Authors Nagy, A, Kozma, G T, Bojszkó, a, Krikovszky, D, Falus, A, Szalai, C
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 01.06.2002
Subjects
Allergies
Allergy
Asthma
Blood
Chemokines
Control Groups
Food allergies
Genotype & phenotype
Genotypes
Goodness of Fit
Hospitals
Hungarian
Mutation
Neonates
Patients
Pediatrics
Physicians
Population
Scientific Research
Statistical Analysis
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Summary:Aims: To investigate whether the presence of the CCR5Δ32 allele was associated with atopy or asthma. Methods: A total of 118 children with asthma, 145 children with non-asthmatic, but allergic phenotype, and 303 children without allergic or asthmatic disorders were studied. Results: There were no significant differences in the frequency of CCR5Δ32, or in the distributions of genotypes between the groups. The relative eosinophil blood count was slightly lower in patients with heterozygous genotype, than in patients with wild type genotype. Conclusion: No association was found between the susceptibility of allergy or asthma and the functional deficient CCR5Δ32 allele.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.86.6.426