Leprosy Diagnostic Test Development As a Prerequisite Towards Elimination: Requirements from the User's Perspective e0004331

In low-prevalence settings, for any test not 100% predictive, it is likely that most positives will be false positives. [...]to improve the predictive value, high-risk groups, such as skin clinic attendees or household contacts, need to be identified and targeted for testing. Both cellular and humor...

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Bibliographic Details
Published inPLoS neglected tropical diseases Vol. 10; no. 2
Main Authors Bahmanyar, Edith Roset, Smith, William Cairns, Brennan, Patrick, Cummings, Ray, Duthie, Malcolm, Richardus, Jan Hendrik, Saunderson, Paul, Shwe, Tin, Rosen, Steven, Geluk, Annemieke
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 01.02.2016
Subjects
Antigens
Biomarkers
Diagnostic tests
Disease
Funding
Infections
Leprosy
Mathematical models
Tropical diseases
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Summary:In low-prevalence settings, for any test not 100% predictive, it is likely that most positives will be false positives. [...]to improve the predictive value, high-risk groups, such as skin clinic attendees or household contacts, need to be identified and targeted for testing. Both cellular and humoral immunity against M. leprae determine the outcome of infection. [...]tests that simultaneously detect biomarkers specific for both types of immune responses are the targets for a test for detection of asymptomatic M. leprae infection and hence progression of infection to clinical disease [16].
ISSN:1935-2727
1935-2735
DOI:10.1371/journal.pntd.0004331