Scribble acts as an oncogene in E[mu]-myc-driven lymphoma

Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor i...

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Bibliographic Details
Published inOncogene Vol. 35; no. 9; p. 1193
Main Authors Hawkins, E D, Oliaro, J, Ramsbottom, K M, Newbold, A, Humbert, P O, Johnstone, R W, Russell, S M
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group 03.03.2016
Subjects
Cells
Lymphoma
Proteins
Tumors
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Summary:Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor in haematological malignancies. Using the E-myc model of Burkitts lymphoma we investigated the role of Scribble in lymphomagenesis. We found that contrary to its well-documented tumour suppressor role in epithelial tissue, loss of Scribble expression delayed the expansion of peripheral B cells and delayed the onset of E-myc-driven lymphoma. This was despite upregulated ERK phosphorylation levels in Scribble-decient tumours, which are associated with loss of Scribble expression and the development of more aggressive Burkitts lymphoma. Interestingly, the developmental stage of lymphoma was unaffected by Scribble expression challenging any role for Scribble in fate determination in the haematopoetic lineage.
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2015.167