THE ASSESSMENT OF BIOLOGICAL MARKERS IN PATIENTS WITH PREECLAMPSIA WHEN AN INFLAMMATORY PROCESS APPEARS

• Published in: Journal of Experimental and Molecular Biology Vol. 16; no. 2; p. 77
• Main Authors: Crauciuc, Eduard, Mihalceanu, Elena, Bratu, Mariana, Toma, Ovidiu, Crauciuc, Dragos
• Format: Journal Article
• Language: English
• Published: Iasi Universitatea "Alexandru Ioan Cuza" 01.04.2015
• Subjects: Biomarkers; Inflammation; Preeclampsia; Pregnancy
• ISSN: 2601-6974; 2601-6974

Preeclampsia represents a pathological state that is specific to regnancy, is characterized by high blood pressure de novo and significant proteinuria and appears after 20 weeks of pregnancy. The continuously increasing mortality caused by preeclampsia in our country totally justifies the fact that all efforts are directed towards primary and secondary prevention of the disease and underlines the necessity of urgent intervention at population level, together with the implementation of a screening programme that is able to reduce the impact of this condition on the mother and the baby. The cases were gathered between 2003 and 2014. The patients were selected by studying the observation charts of the pregnant women hospitalized in "Cuza Voda" Clinical Hospital of Obstetrics and Gynecology Iasi, having a pregnancy over 20 weeks, who came for a specialized consult and who were harvested CRP, without an infectious context or prematurely and spontaneously ruptured membranes. The comparison of the lab markers for the pregnant women with severe preeclampsia, depending on the plasmatic level of CRP over 12 mg/l, showed significantly higher values of fibrinogen, LDH, GOT, GPT, serum blood urea nitrogen, creatinine and urine proteins, while the mean number of white cells was significantly reduced (p<0,05). The study confirms the change in the inflammatory process markers, the hepatic and kidney function, associated with a high plasmatic level of CRP for pregnant women with severe preeclampsia.