Determination of Mean Vessel Density Baseline for Normal Buccal Mucosa: A Histomorphometric Study

Angiogenesis or neovascularization, the process that leads to formation of the new blood vessels plays a major role not only in the embryogenesis, growth and development of normal tissues but also in various kinds of pathological disorders such as diabetic retinopathy, rheumatoid arthritis, lichen p...

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Bibliographic Details
Published inJournal of international oral health Vol. 7; no. 10; p. 24
Main Authors Shobha, B V, Pujari, Ravi Kumar, Vidya, N, Dash, Bishwajeet
Format Journal Article
LanguageEnglish
Published Mumbai Medknow Publications & Media Pvt. Ltd 01.10.2015
Subjects
Angiogenesis
Blood
Growth factors
Medical prognosis
Medical research
Metastasis
Methods
Microscopy
Mucous membrane
Statistical analysis
Studies
Tumors
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Summary:Angiogenesis or neovascularization, the process that leads to formation of the new blood vessels plays a major role not only in the embryogenesis, growth and development of normal tissues but also in various kinds of pathological disorders such as diabetic retinopathy, rheumatoid arthritis, lichen planus, and squamous cell carcinoma. Mean vessel density can be a measure of angiogenesis. The study sample consisted of twenty cases of the normal buccal mucosa (NBM). The twenty samples from the archive were stained using hematoxylin and eosin (H and E) and Masson Trichrome (MT). The stained sections were analyzed using the Image analysis software. Statistical analysis used: SPSS 13.0 statistical software was used. The mean vessel density (MVD) of all the cases in H and E was combined at 0.1002 and for MT 0.2050. The difference of MVD between H and E and MT was statistically significant. MVD can be used as an indicator of turn-on and turn-offphenomenon of angiogenesis. MVD can also be used as a supplement to other diagnostic techniques. The buccal mucosa baseline level MVD for was 11.5%. More statistics is required to standardize baseline levels for different sites of oral mucosa, age, and gender groups. Hence, the increase or decrease of angiogenesis can be easily compared to the baseline values.
ISSN:0976-7428
0976-1799