GW26-e1336 Myocardial Protection by MiR-126 Against Ischemia/Reperfusion Injury Through Suppression of GSK-3[beta]

Stretch or enforced expression of miR-126 significantly decreased I/R-induced myocardial infarct size by 42% and attenuated I/R-induced myocardial apoptosis, together with down-regulation of glycogen synthase kinase 3 beta (GSK-3β) (p<0.05).

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 66; no. 16; p. C40
Main Authors Wang, Qian, Zhu, Jianbing, Wang, Lin, Yu, Wenjun, Zhang, Renfeng, Qiao, Lihua, Ge, Xinyue, Lou, Jiatao
Format Journal Article
LanguageEnglish
Published New York Elsevier Limited 20.10.2015
Subjects
Apoptosis
Cardiology
Ischemia
Kinases
Rodents
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Summary:Stretch or enforced expression of miR-126 significantly decreased I/R-induced myocardial infarct size by 42% and attenuated I/R-induced myocardial apoptosis, together with down-regulation of glycogen synthase kinase 3 beta (GSK-3β) (p<0.05).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.1178