Association between ^sup 18^F-FDG uptake and molecular subtype of breast cancer
To determine whether ^sup 18^F-FDG uptake in breast cancer correlates with immunohistochemically defined subtype and is able to predict molecular subtypes. This retrospective study involved 306 patients with 308 mass-type invasive breast cancers (mean size 2.65 cm, range 1.0-15.0 cm) who underwent ^...
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Published in | European journal of nuclear medicine and molecular imaging Vol. 42; no. 9; p. 1371 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Heidelberg
Springer Nature B.V
01.08.2015
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Subjects | |
Online Access | Get full text |
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Summary: | To determine whether ^sup 18^F-FDG uptake in breast cancer correlates with immunohistochemically defined subtype and is able to predict molecular subtypes. This retrospective study involved 306 patients with 308 mass-type invasive breast cancers (mean size 2.65 cm, range 1.0-15.0 cm) who underwent ^sup 18^F-FDG PET/CT before therapy. The correlations between primary tumour ^sup 18^F-FDG uptake on PET/CT, expressed as SUVmax, and clinicopathological findings and molecular subtype, i.e. luminal A, luminal B (HER2-negative), luminal B (HER2-positive), HER2-positive and triple-negative, were analysed. The predictors of these subtypes were investigated. The mean SUVmax of the 308 tumours was 5.33±3.63 (range 1.15-19.01). Among the subtypes of the 308 tumours, 87 (28.2 %) were luminal A, 111 (36.0 %) were luminal B (HER2-negative), 31 (10.1 %) were luminal B (HER2-positive), 26 (8.4 %) were HER2-positive and 53 (17.2 %) were triple-negative, and the corresponding mean SUVmax were 3.41±2.07 (range 1.18-14.30), 5.17±3.52 (range 1.35-19.01), 6.57±3.84 (range 1.42-15.58), 7.55±3.63 (range 2.30-13.60) and 6.97±4.17 (range 1.15-16.06), respectively. A cut-off value of 3.60 yielded 70.1 % sensitivity and 66.1 % specificity with an area under the receiver operating characteristics curve (AUC) of 0.734 for predicting that a tumour was of the luminal A subtype. A cut-off value of 6.75 yielded 65.4 % sensitivity and 75.2 % specificity with an AUC of 0.704 for predicting a HER2-positive subtype. SUVmax, a metabolic semiquantitative parameter, shows a significant correlation with the molecular subtype of breast cancer, and is useful for predicting the luminal A or HER2-positive subtype. |
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ISSN: | 1619-7070 1619-7089 |
DOI: | 10.1007/s00259-015-3070-1 |