Smad7, the major negative regulator of TGF-[beta] signaling, modulates cerulein-induced pancreatic fibrosis

Conclusion: Taken together, we concluded that lack of a functional Smad7 gene resulted in enhanced TGF-Î² signaling leading to a more severe fibrotic response. [...]it presents a valuable target for anti-fibrosis therapy.

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Bibliographic Details
Published in	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 15; no. 3; p. S12
Main Authors	Li, Xuan, Nania, Salvatore, Fejzibegovic, Nino, Heuchel, Rainer, Löhr, Matthias
Format	Journal Article
Language	English
Published	Philadelphia Elsevier Limited 01.06.2015
Subjects	Collagen Pancreas Rodents
Online Access	Get full text

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Summary:	Conclusion: Taken together, we concluded that lack of a functional Smad7 gene resulted in enhanced TGF-Î² signaling leading to a more severe fibrotic response. [...]it presents a valuable target for anti-fibrosis therapy.
ISSN:	1424-3903 1424-3911
DOI:	10.1016/j.pan.2015.05.078