Serological Surveillance Development for Tropical Infectious Diseases Using Simultaneous Microsphere-Based Multiplex Assays and Finite Mixture Models e3040

• Published in: PLoS neglected tropical diseases Vol. 8; no. 7
• Main Authors: Fujii, Yoshito, Kaneko, Satoshi, Nzou, Samson Muuo, Mwau, Matilu, Njenga, Sammy M, Tanigawa, Chihiro, Kimotho, James, Mwangi, Anne Wanjiru, Kiche, Ibrahim, Matsumoto, Sohkichi, Niki, Mamiko, Osada-Oka, Mayuko, Ichinose, Yoshio, Inoue, Manabu, Itoh, Makoto, Tachibana, Hiroshi, Ishii, Kazunari, Tsuboi, Takafumi, Yoshida, Lay Myint, Mondal, Dinesh, Haque, Rashidul, Hamano, Shinjiro, Changoma, Mwatasa, Hoshi, Tomonori, Kamo, Ken-ichi, Karama, Mohamed, Miura, Masashi, Hirayama, Kenji
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.07.2014
• Subjects: Acquired immune deficiency syndrome; AIDS; Antigens; Cholera; Flow cytometry; HIV; Human immunodeficiency virus; Infectious diseases; Malaria; Population; Studies; Surveillance; Tropical diseases; Tuberculosis; Kenya
• ISSN: 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0003040

In sub-Saharan Africa, the impact of NTDs as a group is comparable to that of malaria and tuberculosis; however, NTDs collectively receive less attention and research funding than human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), tuberculosis, or malaria, despite the fact that NTDs affect an estimated one billion people in tropical and subtropical climates [1]. According to the World Health Organization, approximately 74% of the affected population simultaneously harbors two NTDs; 18% three; 13% four; 9% five; 11% six; and 8% seven or more NTDs [2]. [...]the equipment (assay machine) for the microsphere-based multiplex serological assay is not inexpensive (about US$ 80,000). Because the manipulation of the device is simple and easy, we would encourage the establishment of a centralized system of the assays with a blood sampling framework from geographically wider areas; filter paper sampling or dried blood spot sampling would be a good option for such centralized surveillance system [44].