Characterization of Aedes aegypti Innate-Immune Pathways that Limit Chikungunya Virus Replication e2994

Once the virus is detected in saliva, the mosquito becomes competent for transmission to the next vertebrate host [1], [2]. [...]interactions between the replicating virus and the mosquito immune defence system produce an outcome that can influence subsequent viral transmission, as shown for the fla...

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Published inPLoS neglected tropical diseases Vol. 8; no. 7
Main Authors McFarlane, Melanie, Arias-Goeta, Camilo, Martin, Estelle, Lulla, Aleksei, Mousson, Laurence, Rainey, Stephanie M, Misbah, Suzana, Schnettler, Esther, Donald, Claire L, Merits, Andres, Kohl, Alain, Failloux, Anna-Bella
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 01.07.2014
Subjects
Chikungunya virus
Colleges & universities
Experiments
Gene expression
Genomes
Immune system
Insects
Mosquitoes
Tropical diseases
Viruses
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Summary:Once the virus is detected in saliva, the mosquito becomes competent for transmission to the next vertebrate host [1], [2]. [...]interactions between the replicating virus and the mosquito immune defence system produce an outcome that can influence subsequent viral transmission, as shown for the flavivirus dengue (DENV) [3]. [...]we demonstrated that the exogenous RNAi pathway plays a vital role in limiting CHIKV replication in cell culture and in mosquitoes.
ISSN:1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002994