The use of saliva as a practical and feasible alternative to urine in large-scale screening for congenital cytomegalovirus infection increasesinclusion and detection rates

INTRODUCTION: Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV) infection, it can be difficult to obtain in newborns. The aim of this study was to compare the efficiency of detection of congenital CMV infection in saliva and urine samples....

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Published inRevista da Sociedade Brasileira de Medicina Tropical Vol. 48; no. 2; p. 206
Main Authors Emanuelle, Santos despaceCarvalho Cardoso, Bruna, Laís Santos de Jesus, Luciano, Gama da Silva, Sandra, Mara Bispo Sousa, Sandra, Rocha Gadelha, Lauro, Juliano Marin
Format Journal Article
LanguageEnglish
Published Rio de Janeiro Sociedade Brasileira de Medicina Tropical 01.03.2015
Subjects
Body fluids
Congenital diseases
Medical diagnosis
Newborn babies
Urine
Viral infections
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Summary:INTRODUCTION: Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV) infection, it can be difficult to obtain in newborns. The aim of this study was to compare the efficiency of detection of congenital CMV infection in saliva and urine samples. METHODS: One thousand newborns were included in the study. Congenital cytomegalovirus deoxyribonucleic acid (DNA) was detected by polymerase chain reaction (PCR). RESULTS: Saliva samples were obtained from all the newborns, whereas urine collection was successful in only 333 cases. There was no statistically significant difference between the use of saliva alone or saliva and urine collected simultaneously for the detection of CMV infection. CONCLUSIONS: Saliva samples can be used in large-scale neonatal screening for CMV infection.
ISSN:0037-8682
1678-9849
DOI:10.1590/0037-8682-0200-201