Organoklorovi insekticidi - mehanizmi toksicnog djelovanja/Organochlorinated insecticides - mechanisms of toxic action

Organochlorine insecticides are a group of highly persistent pesticides, derivatives of aliphatic or aromatic hydrocarbons, very resistant to biodegradation. The basic mechanisms of the majority insecticides of this group are expressed as stimulation of central nervous system that occurs due to non-...

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Published inHrvatski časopis za prehrambenu tehnologiju, biotehnologiju i nutricionizam Vol. 9; no. 3/4; p. 97
Main Authors Murati, Teuta, Simic, Branimir, Kniewald, Jasna, Pleadin, Jelka, Kmetic, Ivana
Format Journal Article
LanguageCroatian
Published Zagreb Croatian Society of Food Technologists, Biotechnologists and Nutritionists 01.07.2014
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Summary:Organochlorine insecticides are a group of highly persistent pesticides, derivatives of aliphatic or aromatic hydrocarbons, very resistant to biodegradation. The basic mechanisms of the majority insecticides of this group are expressed as stimulation of central nervous system that occurs due to non-GABAergic effect, and additionally many of them inhibit specific ATPases in neurons. Due to the chemical structure they include chlorinated cyclodienes, DDT-type insecticides, hexachlorocyclohexanes and toxaphene. Molecular mechanisms of toxicity of organochlorine insecticides include alteration of signaling pathways in the cell as a result of endocrine modulation and/or oxidative stress. Numerous adverse effects on human health caused by the exposure to organochlorine insecticides are scientifically proven, such as neurotoxicity, immunotoxicity, disruption of endocrine homeostasis, reproductive system toxicity and carcinogenic potential. This article provides analysis of the insecticidal activity mechanisms and a review of the harmful effects on human health.
ISSN:1847-3423
1847-7461