EMERGENCY ROOM: AN UNRECOGNIZED SOURCE OF EXTENDED-SPECTRUM [Beta]-LACTAMASE PRODUCING ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE

Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae are the leading causes of hospital-associated infections, but community-acquired cases are increasingly being reported. This study determined the prevalence of ESBL-producing E. coli and K. pneumoniae carriers,...

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Published inSoutheast Asian journal of tropical medicine and public health Vol. 46; no. 1; p. 51
Main Authors Pornsinchai, Pornsook, Chongtrakool, Piriyaporn, Diraphat, Pornphan, Siripanichgon, Kanokrat, Malathum, Kumthorn
Format Journal Article
LanguageEnglish
Published Bangkok Central Coordinating Board, SEAMEO-TROPMED Project 01.01.2015
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Summary:Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae are the leading causes of hospital-associated infections, but community-acquired cases are increasingly being reported. This study determined the prevalence of ESBL-producing E. coli and K. pneumoniae carriers, their bla genes and risk factors of 452 patients admitted to the emergency room of Ramathibodi Hospital, Mahidol University, Bangkok, Thailand between April and August 2011. Prevalence of ESBL-producing E. coli and K. pneumoniae from rectal swabs was 16.5% and 1.0%, respectively. All ESBL-producing isolates were susceptible to imipenem, meropenem and ertapenem. The majority of ESBL-producing E. coli isolates showed very high resistance to cefotaxime and ceftriaxone. Detailed epidemiologic and clinical characteristics of ER patients with history of prior hospital visits should be carried out to identify the ESBL-producing organisms they have acquired in order to institute appropriate treatment for these patients as well as control measures against further dissemination of these life-threatening organisms.
ISSN:0125-1562