Synthesis, resolution, and determination of absolute configuration of protected [alpha]-ethynylphenylalanine enantiomers
Racemic-protected [alpha]-ethynylphenylalanine was synthesized from dl-2-benzylserine using [alpha]-benzylserinal as key intermediate and was successfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrat...
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| Published in | Amino acids Vol. 47; no. 5; p. 899 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Vienna
Springer Nature B.V
01.05.2015
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| Online Access | Get full text |
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| Abstract | Racemic-protected [alpha]-ethynylphenylalanine was synthesized from dl-2-benzylserine using [alpha]-benzylserinal as key intermediate and was successfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism. |
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| AbstractList | Racemic-protected [alpha]-ethynylphenylalanine was synthesized from dl-2-benzylserine using [alpha]-benzylserinal as key intermediate and was successfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism. |
| Author | Jean, M Meffre, P Naubron, J-v Benfodda, Z Rolland, V Bénimélis, D |
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| DOI | 10.1007/s00726-015-1917-1 |
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| Snippet | Racemic-protected [alpha]-ethynylphenylalanine was synthesized from dl-2-benzylserine using [alpha]-benzylserinal as key intermediate and was successfully... |
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| Title | Synthesis, resolution, and determination of absolute configuration of protected [alpha]-ethynylphenylalanine enantiomers |
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