Synthesis, resolution, and determination of absolute configuration of protected [alpha]-ethynylphenylalanine enantiomers

Racemic-protected [alpha]-ethynylphenylalanine was synthesized from dl-2-benzylserine using [alpha]-benzylserinal as key intermediate and was successfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrat...

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Bibliographic Details
Published inAmino acids Vol. 47; no. 5; p. 899
Main Authors Benfodda, Z, Bénimélis, D, Jean, M, Naubron, J-v, Rolland, V, Meffre, P
Format Journal Article
LanguageEnglish
Published Vienna Springer Nature B.V 01.05.2015
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Summary:Racemic-protected [alpha]-ethynylphenylalanine was synthesized from dl-2-benzylserine using [alpha]-benzylserinal as key intermediate and was successfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-015-1917-1