GABAAReceptor Trafficking-Mediated Plasticity of Inhibitory Synapses

Proper developmental, neural cell-type-specific, and activity-dependent regulation of GABAergic transmission is essential for virtually all aspects of CNS function. The number of GABAAreceptors in the postsynaptic membrane directly controls the efficacy of GABAergic synaptic transmission. Thus, regu...

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Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 70; no. 3; p. 385
Main Authors Luscher, Bernhard, Fuchs, Thomas, Kilpatrick, Casey L
Format Journal Article
LanguageEnglish
Published Cambridge Elsevier Limited 12.05.2011
Subjects
Behavior
Ligands
Medical research
Phosphorylation
Rodents
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Summary:Proper developmental, neural cell-type-specific, and activity-dependent regulation of GABAergic transmission is essential for virtually all aspects of CNS function. The number of GABAAreceptors in the postsynaptic membrane directly controls the efficacy of GABAergic synaptic transmission. Thus, regulated trafficking of GABAAreceptors is essential for understanding brain function in both health and disease. Here we summarize recent progress in the understanding of mechanisms that allow dynamic adaptation of cell surface expression and postsynaptic accumulation and function of GABAAreceptors. This includes activity-dependent and cell-type-specific changes in subunit gene expression, assembly of subunits into receptors, as well as exocytosis, endocytic recycling, diffusion dynamics, and degradation of GABAAreceptors. In particular, we focus on the roles of receptor-interacting proteins, scaffold proteins, synaptic adhesion proteins, and enzymes that regulate the trafficking and function of receptors and associated proteins. In addition, we review neuropeptide signaling pathways that affect neural excitability through changes in GABAAR trafficking.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2011.03.024